As human ages, skin becomes lax and loses elasticity, firmness & thickness. Besides, certain environment, occupation, stress, genetics & lifestyle can also induce premature aging (which needs to be treated intensively).
Wrinkle is most obvious sign of aging. Removal of wrinkle consists several treatments in the clinic de novo such as Botox, Filler, Thread Lift & Radio Frequency treatments. While wrinkles are away, one can once again feel their youth.